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Twins showering men

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A pair of twin sisters who suffered from severe OCD that drove them to shower for 10 hours a day have been found dead in a suspected suicide pact.

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We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. The aetiology is unknown. A specific genetic mutation has not yet been found. To our knowledge, this is the first report of aquagenic urticaria in monozygotic twins, further supporting a genetic component to this disease.

We describe the case of 18 year old twin brothers who presented with aquagenic urticaria. The aetiology is not understood. They were both keen triathletes and were therefore frequently exposed to water. The wheals were induced by both hot and cold water. They would resolve spontaneously after about one hour, leaving no residual mark. Neither brother had ever experienced any associated angioedema.

Exercise such as running would only induce itching. There was no history of atopy and both brothers were in good general heath and were not taking any regular medications. The family history was unknown as the brothers had been adopted. The symptoms were controlled by taking prophylactic cetirizine 10mg once per day. Symptoms often start in puberty. Differential diagnoses include aquagenic pruritus, where exposure to water induces pruritus but no visible skin lesions, and cholinergic urticaria, where wheals develop in response to heat, exertion, sweating or emotional stress.

It has been suggested that water interacting with sebum or sebaceous glands can produce a toxin causing degranulation of mast cells, leading to histamine release and wheal formation.

An alternative explanation has been that water-soluble antigens in the epidermis diffuse into the dermis and cause a histamine mediated reaction. Oral antihistamines are used as first line treatment, up to four times the standard single daily dose. Some of these cases have been reported in association with other conditions, a few of which are genetically linked. For example, Pitarch et al. These genes map to chromosomes 17p12, 22q They postulated that although the association could be a coincidence, it might constitute an association of genetic loci.

Treudler er al [ 2 ] reported an association of familial aquagenic urticaria with familial lactose intolerance over three generations. They described a male patient with aquagenic urticaria whose grandmother, mother, aunt and cousin were all affected. The patient, mother and grandmother were also affected by familial lactose intolerance. Familial lactose intolerance is caused by a deficiency of the enzyme lactase which is encoded on chromosome 2, a different genetic locus to the mutations causing Bernard-Soulier syndrome chromosomes 17, 22 and 3.

To the best of our knowledge, this is the first case report of aquagenic urticaria in monozygotic twins, further supporting the notion that there is a genetic component to this type of urticaria, as suggested by others.

Written informed consent was obtained from the patients for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in Chief of this journal. CF provided the case history. AK carried out the literature review and wrote the discussion. All authors read and approved the final manuscript. National Center for Biotechnology Information , U. World Allergy Organ J. Published online Jan Anneke C Kai 1 and Carsten Flohr 1, 2.

Author information Article notes Copyright and License information Disclaimer. Corresponding author. Anneke C Kai: ku. Received Sep 9; Accepted Jan This article has been cited by other articles in PMC. Abstract We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. Keywords: Urticaria, Aquagenic. Background We describe the case of 18 year old twin brothers who presented with aquagenic urticaria.

Case presentation 18 year old identical twin brothers were referred to our tertiary referral centre urticaria clinic with a three year history of aquagenic urticaria.

Open in a separate window. Figure 1. Figure 2. Conclusions To the best of our knowledge, this is the first case report of aquagenic urticaria in monozygotic twins, further supporting the notion that there is a genetic component to this type of urticaria, as suggested by others. Consent Written informed consent was obtained from the patients for publication of this Case Report and any accompanying images. Competing interests The authors declare that they have no competing interests.

Familial aquagenic urticaria and bernard-soulier syndrome. Familial aquagenic urticaria associated with familial lactose intolerance. J Am Acad Dermatol. Familial aquagenic urticaria: report of two cases and literature review.

An Bras Dermatol. Familial aquagenic urticaria. Evidence that water acts as a carrier for an epidermal antigen in aquagenic urticaria. Calif Med.

Aquagenic urticaria. Genetic abnormalities of Bernard-Soulier syndrome. Int J Hematol. Support Center Support Center. External link. Please review our privacy policy.

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Twins showering men

Twins showering men

Twins showering men

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Aquagenic urticaria in twins

A pair of twin sisters who suffered from severe OCD that drove them to shower for 10 hours a day have been found dead in a suspected suicide pact. Sara and Amanda Eldritch, 33, were found dead with gunshot wounds in a car near their home in Royal Gorge, Colorado, on Friday — with local cops saying they believed their deaths were a pre-agreed suicide pact.

The siblings suffered from such a severe fear of germs and dirt that they also went through five bottles of rubbing alcohol a day, and disinfected their skin with bleach until their eyebrows turned orange. They also found leaving home so stressful that if they had to do so, the twins would starve themselves for hours beforehand to avoid using public restrooms.

Sara and Amanda appear to have killed themselves despite having pioneering deep brain stimulation surgery in that it was hoped would alleviate their mental anguish. It uses electrical currents in an attempt to regulate the brain patterns which can cause neural conditions. And I feel like I can deal with it.

But sadly the suicidal thoughts that the sisters said had plagued them since the age of 13 now appear to have overwhelmed them. Follow Metro. Share this article via facebook Share this article via twitter Share this article via messenger Share this with Share this article via email Share this article via flipboard Copy link. Share this article via facebook Share this article via twitter. Today's Best Discounts.

Twins showering men